uMatrix & uBlock
uBlock is my blacklist. uMatrix is my whitelist. For various reasons, I occasionally need to skip the whitelist, but I never had a reason to turn off the blacklist in a few years of using uBlock. - HN
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I use them together, uMatrix as a fine grained control tool where I can setup a saved profile and click-allow until functionality & appearance are acceptable to me, and for ‘one-off’ or ‘fuck-it no time’ situations I just toggle uMatrix off. It is very rare I have to turn off uBlock Origin as well (the nuclear option). This leaves me four-five quick clicks away from the median or average user experience.
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the main difference is that for uBlock you can subscribe to really good lists, collected and curated by a lot of people - so it is “defauly allow, except for these…”, whereas uMatrix is “default deny, except for what you explicitly allowed”.
I run both, occasionally have to allow something in uMatrix, never have to turn uBlock off.